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KMID : 0854720090290020089
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Korean Journal of Asthma, Allergy and Clinical Immunology
2009 Volume.29 No. 2 p.89 ~ p.95
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The Effects of Extracts from Green Tea, Guajava Leaves and Rose Petals on Allergic Rhinitis: A Randomized Double Blind Control Study
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Kim Seong-Yeol
Kim Joo-Hee
Son Kyeong-Min
Jeong Jong-Moon
Park Sung-Hoon
Hwang Yong-Il
Jang Seung-Hoon
Kim Dong-Kyu
Jung Ki-Suck
Kang Hye-Ryun
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Abstract
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Background: Allergic rhinitis causes itching, sneezing, profuse watery rhinorrhea, and nasal congestion. There is no medication to cure allergic rhinitis so far except for allergen immunotherapy which can be performed in limited patients. Therefore, people with allergic rhinitis cannot be away from their medication for their lives once the condition developed. BENDU381, a nutraceutical composed of extracts from green tea (Camellia sinensis), guajava leaves (Psidium guajava), and rose petals (Rosa hybrida), was proved to improve allergic inflammation through several in vitro and in vivo trials.
Objective: This study was performed to evaluate the therapeutic effect of BENDU381 on allergic rhinitis.
Method: Sixty three patients with perennial allergic rhinitis were received two capsules of BENDU381 (200 mg/capsule) or placebo, twice every day, for four weeks. Nasal symptom score and quality of life (QoL) related with rhinitis were monitored to evaluate the effect of BENDU381 on allergic rhinitis.
Result: BENDU381 showed significant improvements in symptoms related with allergic rhinitis (itching, sneezing, and watery rhinorrhea) over placebo. In addition, BENDU381 reduced skin reactivity to sensitized perennial allergens. QoL related with rhinitis also remarkably improved with the treatment of BENDU381.
Conclusion: BENDU381 was proved to be helpful in relieving rhinitis symptoms and improving QoL without noticeable side effects.
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KEYWORD
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Allergic rhinitis, Dietary supplements, Camellia sinensis, Psidium guajava, Rosa hybrida
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